Track your Manuscript
Enter Correct Manuscript Reference Number:
Get Details
Top Editors
No Editor added
Top Reviewers
No Reviewer added
Why Us
Open Access
Rapid publication
Lifetime hosting
Free indexing service
Free promotion service
More citations
Search engine friendly
Go Back       Himalayan Journal of Community Medicine and Public Health | 1 1 | Oct. 5, 2020
431 Downloads2191 Views

DOI : N/A       Download PDF       HTML       XML

Unmonitored exercise or behavioral intervention may not reflect increased muscle mass on MRI in myotonic dystrophy type-1

Josef Finsterer, MD, PhD1, Carla A. Scorza2, Ana C Fiorini, MD3, and Fulvio A. Scorza, MD2

1Klinik Landstrasse, Vienna, Messerli Institute, Austria

2Disciplina de Neurociência. Escola Paulista de Medicina/Universidade Federal de São Paulo/. (EPM/UNIFESP). São Paulo, Brasil

3Programa de Estudos Pós-Graduado em Fonoaudiologia. Pontifícia Universidade Católica de São Paulo (PUC-SP). Departamento de Fonoaudiologia. Escola Paulista de Medicina/Universidade Federal de São Paulo (EPM/UNIFESP). São Paulo, Brasil

Article History

Received: 25.09.2020

Accepted: 04.10.2020

Published: 10.10.2020

Keywords: exercise, training, muscle mass, muscle MRI, myotonic dystrophy, fatigue.


With interest we read the article by Heskamp, L. et al., 2020 about a prospective muscle MRI-study of 27 patients with myotonic dystrophy type-1 (MD1) who underwent either cognitive behavioural therapy (n=18) or graded exercise plus behavioural therapy (n=9). It was concluded that behavioural intervention targeting physical activity increases lower extremity muscle cross-sectional area (Heskamp, L. et al., 2020). We have the following comments and concerns.

A shortcoming of the study is that it is unclear which patients described previously (Heskamp, L. et al., 2019; & van Engelen, B., & OPTIMISTIC Consortium. 2015) were included in the present study. In the article to which the authors refer, 33 MD1 patients were investigated (Heskamp, L. et al., 2019) but the present study included only 27 patients since only these 27 underwent follow-up MRIs. Which were the 6 patients that were excluded and why?

A further shortcoming is the application of the DM1-Activ scale to document graded exercise. Since the scale consists of 25 items describing activities of daily living, which can be assessed at three grades by the patient, the total “exercise” carried out was different in each patient, thus not standardised. We should know if a “graded exercise module” means that the patient filled in the DM1-Activ scale repeatedly. Ii is unclear which cut-offs were applied to define “exercise”. Furthermore, we should know how often during the 10 months observational period the form was filled out and how it was controlled that patients filled out the form honestly.

Another shortcoming is that comparisons were carried out only between the standard care and the intervention group but not between the graded exercise and behavioural therapy group. This comparison is crucial to see if exercise truly had a better effect than behavioural therapy alone.

Lastly, MD1 is a multisystem disease, affecting additionally the endocrine organs. Since muscle performance, composition, and morphology may strongly depend on endocrinologic parameters (Horwath, O. et al., 2020), we should know if hormone levels differed between patients or groups and between inclusion and follow-up. Of particular interest are FGF-21 levels, which are increased in MD1 (Lovadi, E. et al., 2017).

Overall, it cannot be excluded that the MRI changes reported reflect the effect of behavioural therapy alone or variable affection of endocrine organs but do not reflect graded exercise at all.


  1. Heskamp, L., Okkersen, K., van Nimwegen, M., Ploegmakers, M. J., Bassez, G., Deux, J. F., ... & OPTIMISTIC Consortium. (2020). Quantitative Muscle MRI Depicts Increased Muscle Mass after a Behavioral Change in Myotonic Dystrophy Type 1. Radiology, 192518.

  2. Heskamp, L., van Nimwegen, M., Ploegmakers, M. J., Bassez, G., Deux, J. F., Cumming, S. A., ... & Heerschap, A. (2019). Lower extremity muscle pathology in myotonic dystrophy type 1 assessed by quantitative MRI. Neurology92(24), e2803-e2814.

  3. Horwath, O., Apró, W., Moberg, M., Godhe, M., Helge, T., Ekblom, M., ... & Ekblom, B. (2020). Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women. Journal of Applied Physiology128(5), 1240-1250.

  4. Lovadi, E., Csereklyei, M., Merkli, H., FüLöp, K., Sebők, Á., Karcagi, V., ... & Pál, E. (2017). Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases. Muscle & nerve55(4), 564-569.

  5. van Engelen, B., & OPTIMISTIC Consortium. (2015). Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): study protocol for randomised controlled trial. Trials16(1), 224.


Copyright © 2020 Inlight Publisher (IARCON INTERATIONAL LLP). All Rights Reserved.