Introduction: Children are the nation’s supremely important asset who determines the future of the nation. Any input into the health of the children today will be an investment since they are the adults of next decade. Epilepsy is the common neurological condition in the children. Most children spend nearly half their waking hours with their teachers and school personnel. It is important to consider the knowledge that teachers may have regarding childhood epilepsy and its management. Objectives: To assess the pre-test knowledge regarding epilepsy management in school children among teachers, to develop and administer the structured teaching program on knowledge regarding epilepsy management, to evaluate the effectiveness of structured teaching program on knowledge regarding epilepsy management, to find out the association between knowledge regarding epilepsy management with their selected demographic variables. Methods and material: A pre-experimental one group pre-test post-test design was used. Sample of 30 teachers were selected by using convenience sampling technique. Data was collected using self-structured knowledge questionnaire regarding management of epilepsy in school children. Results: The results of study revealed that, in pre-test 0(0%) of the teachers had good knowledge, 19(63.3%) had average knowledge, 11(36.7%) had poor knowledge whereas in post-test knowledge scores, 28(93.3%) had good knowledge, 2(6.7%) had average knowledge and 0 (0%) had poor knowledge. It was found that there was significant improvement in the post-test knowledge score with ‘t’value 20.232 which was significant at ‘p’ <0.001. Conclusion: Study concluded that the structured teaching programme was effective in increasing the knowledge of teachers regarding management of epilepsy in school children.