Background: COVID-19 has taken a heavy toll on the world, claiming many lives. Health care workers are one of the important pillars for the sustenance of lives. Nurses are at the front line of the outbreak response of current pandemic of COVID-19 and exposed to hazards that put them at risk of infection; their knowledge regarding the pandemic have become even more crucial at this moment. Aims: to assess the Effectiveness of Information Booklet on Knowledge regarding COVID-19 among Staff Nurses working in Indira Gandhi Medical College and Hospital Shimla (HP) Objectives: 1) To assess the level of knowledge regarding COVID-19 among staff nurses. 2) To develop and administer information booklet regarding COVID-19 among staff nurses. 3) To evaluate the effectiveness of information booklet regarding COVID-19 among staff nurses. 4) To find out the association between knowledge score among the staff nurses regarding COVID-19 with selected demographic variables. Methodology: A quantitative research approach was used and research design was pre-experimental one group pre and post test only. Data was collected by using a self-structured questionnaire. Result: The mean post- test knowledge score 21.47 is apparently higher than the mean pre-test knowledge score 15.62. Conclusion: From the study findings, it is revealed that there was significant increase in the knowledge score of the staff nurses after information booklet. Therefore, it was concluded that information booklet was highly effective in improving the knowledge of staff nurses REGARDING COVID-19.