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Go Back       Himalayan Journal of Medicine and Surgery | Volume:4 Issue:6 | Nov. 20, 2023
58 Downloads149 Views

DOI : 10.47310/Hjms.2023.v04i06.001       Download PDF       HTML       XML

Evaluation of the Role of Chemical Peel in the Treatment of Xeroderma Pigmentosum


Basil Hussam Abdulrazaq 1, Haider H. Sadoon 3, Ghassan A. Abdulrazaq 2

1M.B.Ch.B. Plastic surgery specialist, Kirkuk health directorate, Azadi Teaching hospital

2M.B.Ch.B. Plastic surgery and Burn Division Manager, Alkindy Teaching Hospital ,Baghdad, Iraq

3M.B.Ch.B. Specialist Plastic surgeon. Baghdad Al-Rusafa health directorate – Iraq


* Correspondence: Basil Hussam Abdulrazaq.


Abstract

Background: Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by heightened sensitivity to ultraviolet radiation due to a deficiency in the endonuclease enzyme responsible for DNA repair.

Aim: The study aimed to evaluate the role of chemical peels in clearing the skin background in patients with XP and reducing the rate of new lesion development.

Patients and Methods: This study included 14 patients with XP, consisting of 9 males and 5 females, who underwent facial chemical peels using 30% trichloroacetic acid. The study was conducted between March 2011 and May 2012 at Al-Jamhouri Teaching Hospital in Mosul. Evaluation of results was performed by two plastic surgeons and patient satisfaction.

Results: All patients underwent trichloroacetic acid peeling of the entire face, with the number of sessions varying. Specifically, one patient received 3 sessions, another patient received 4 sessions, and one patient received 6 sessions. Eight patients underwent 5 sessions, and three patients received 7 sessions of chemical peels. Patient and parent satisfaction was assessed, with 7 patients reporting high satisfaction and 7 patients indicating moderate satisfaction. Evaluation by two plastic surgeons revealed good results in 5 patients, moderate results in 7 patients, and poor results in 2 patients.

Conclusion: Chemical peels offer a simple, well-tolerated procedure that effectively clears skin background changes and eliminates subclinical premalignant lesions, as diagnosed by fine needle aspiration cytology (FNAC). This procedure exhibits a prophylactic effect in XP patients and yields positive outcomes with minimal complications.


Keywords: Xeroderma pigmentosum, chemical peels, trichloroacetic acid, DNA repair, patient satisfaction, fine needle aspiration cytology, prophylactic effect.



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