Uterus is a vital reproductive organ and is associated with various benign and malignant pathologies. Surgical removal of uterus is known as hysterectomy. It can be performed either through abdominal or vaginal route or with the help of minimal invasive surgical procedures like laparoscope. There is diagnostic and therapeutic significance of performing histopathological examinations of hysterectomy specimens or any surgically excised specimens. The aim of the study was to evaluate clinical indications for hysterectomy and the histopathological features of varied lesions of uterus and cervix and their distribution in relation to age at a tertiary care hospital. This is a retrospective observational study conducted in Department of Obstetrics & Gynecology, Rama Medical College, Hospital & Research Center from July 2019 to March 2020. A total 250 patients were included in the study with age range from 19-70 years. Histopathological examination reports were analyzed and compared with clinical diagnosis. Histopathological examination of all the surgically excised specimens should be done regardless of its benign indication as this helps to correlate with the pre-operative clinical diagnosis and provides the final diagnosis.