Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune inflammatory disorder with varied manifestations ranging from benign skin manifestations to life threatening renal manifestations. Epidemiological data suggests geographical and ethnical differences pointing towards role of both genetic and environmental factors playing their role in phenotypic expression of disease. Various autoimmune markers in the form of autoantibodies have been discovered which correlate with phenotypic expression of disease. There is scarcity of epidemiological data in India of Systemic Lupus Erythematosus owing to lack of studies. This review article is intended to study epidemiological characteristics of the disease in Indian context.