If we think of a common word between the two countries, i.e., Mexico and India, we immediately think of the word, “los indios” meaning "Indians” literally in English however it is used to describe the native Indians in South American countries. If one happens to be an Indian, one cannot help but think that the word is referring to Indians from India. India and Mexico have striking similarities in geo-climatic conditions, biodiversity, physiognomy along with people, cultural and family values, as well as European connections of the colonial era. The history of variations in the meanings and connotations of a word can provide us with information about the evolution of the attitude of a linguistic community to a reality that it interprets. The word "Indian" gives rises to a lot of questions in our minds, perhaps everyone has a "connected" history. This paper looks into some of the cultural and historical similarities of the two countries through a comparative analysis of the Mayas and Aztecs of Mexico with the Indus and Aryan civilizations of India. We use qualitative method of research and have used the theories of Enrique Dussel and his work The invention of the Americas, along with Octavio Paz‟s Glimpses of India are used as reference point. The findings show that there could be a possibility of a shared DNA between the two countries during the neanderthal time of the human evolution, where Indians moved to Mexico to escape from bad weather