Indigenous knowledge is a cultural element of the ethnic group in general and the Khmer ethnic group in particular, contributing to the diversity of ethnic culture. Although it no longer plays an important role as in traditional society, the indigenous knowledge of the Khmer people is still latent as cultural elements, still holding an important position in the present life of the Khmer in Vietnam, such as in social stability, community cohesion, educational development, etc. In this article, the author summarizes the characteristics of Khmer folklore; Indigenous knowledge theory, applied to build a system of indigenous knowledge characteristics of Khmer people. From there, the article proposes the process and some forms of teaching Khmer folklore based on the exploitation of indigenous knowledge of the Khmer in the context of profoundly renewing education in Vietnam today.