Staphylococcus aureus is a pathogen which colonizes the epidermis and nasal passages of the anterior slits, the alimentary canal, the genitourinary tract, and the pharynx. There are numerous ailments that this bacterium can cause, from mild infections of the skin to fatal pneumonia and sepsis. Bacteria from S. aureus can pass easily through one genus to another. The transition from humans to animals. S. aureus infections are zoonotic. It can be spread from animal to person by bites, scratches, working with diseased animal body parts or bones, and skin sores developed during contact with sick or carrier animals. The treatment of infections that caused by S. aureus is complicated by resistance of the antibiotic, and there is no effective vaccination. The incredibly high number of toxins as well as other virulence factors produced by S. aureus, as well as their impact on disease, have sparked ongoing and growing interest.