Coronavirus disease 2019(COVID- 19) was first identified in December 2019 and declared by World Health Organisation(WHO) as a pandemic in March 2020 (Chan, K. H. et al., 2020). This is caused by the Severe Acute Respiratory Syndrome-Corona virus 2(SARS-Cov-2) which initially affects the respiratory tract producing influenza-like symptoms but subsequently involves multiple organ systems resulting in many complications. One of them is arterial and venous thrombosis which can lead to stroke, acute coronary syndrome, acute limb ischemia, and acute mesenteric ischemia (Bhayana, R. et al., 2020). Acute mesenteric ischemia caused by the virus can be due to multiple reasons. The exact pathophysiological mechanism is not well understood, possibilities can be attacking of angiotensin-converting enzyme 2 receptors on enterocyte by the virus leading to inflammation of endothelium and subsequent vascular damage (Escher, R. et al., 2020). Others are hypercoagulability, increase in von Willebrand factor, or shock (Parry, A. H. et al., 2020). Patients having acute mesenteric ischemia can present with abdominal pain, nausea, vomiting, abdominal distension, guarding, or rigidity requiring prompt diagnosis and treatment. Diagnosis can be made by imaging techniques like abdominal radiography, ultrasonography, and computed tomography of abdomen. Among all computed tomography (CT) of abdomen plays an important role and findings like thickened, edematous, dilated bowel and pneumatosis intestinalis are suggestive of bowel ischemia (Fitzpatrick, L. A. et al., 2020). Once the diagnosis is made immediate measures for the management of the patient should be taken. In this case series, we describe five Covid patients who presented with abdominal pain, nausea, vomiting, abdominal distension along with cough, fever, and shortness of breath. Exploratory laparotomy was done in 2 patients in whom the diagnosis was made peroperatively, remaining 3 patients were kept only on anticoagulant therapy. Only one patient survived and 4 patients succumbed to the various complications of the disease.
Case 1
A 45 years, male, presented with cough, fever, sore throat and shortness of breath with decreased oxygen saturation. Nasopharyngeal swab for SARS-Cov-2 rRT-PCR (real time Reverse Transcription-Polymerase chain reaction) was positive and ground glass opacities were present in CT scan of chest. After few days the patient developed abdominal pain, nausea, vomiting, abdominal distension, guarding and rigidity. Radiograph of abdomen was suggestive of intestinal obstruction and exploratory laparotomy was done. Per operative findings were suggestive of gangrenous bowel one foot distal to duodenojejunal flexure up to ileocaecal junction (Figure 1). Gangrenous bowel was resected and proximal jejunostomy was created. Patient developed complications and expired on 6th post-operative day.
Case 2
A 33 years, male, presented with a history of cough, fever, shortness of breath with abdominal pain, nausea and vomiting. On examination, the patient was also having arrhythmias [7], blackening of right hand and forearm suggestive of gangrene of right upper limb and abdominal distension along with features of peritonitis. Nasopharyngeal swab for SARS-Cov-2 rRT-PCR was positive and ground glass opacities were present in CT of chest. CT angiography of right upper limb was done which was suggestive of thrombus in right subclavian artery and CT of abdomen was suggestive of features of superior mesenteric artery thrombus with mesenteric fat stranding and pneumatosis intestinalis (Figure 2). Exploratory laparotomy was done and gangrenous bowel from 1 foot distal to duodenojejunal flexure up to ileocaecal junction was resected and proximal jejunostomy was created. Patient succumbed to complications on 3rd post-oprative day.
Case 3
A 60 years, female, presented with a history of cough, fever, shortness of breath with abdominal pain, nausea and vomiting. On examination patient was having tachycardia, decreased oxygen saturation, abdominal tenderness but no features of peritonitis. Patient was SARS-Cov-2 rRT-PCR positive. There was thrombus in superior mesenteric artery suggestive of acute mesenteric ischemia (Figure 3 A&B). Conservative measures including bowel rest, nasogastric decompression, rehydration was done. Anticoagulant therapy with enoxaparin 0.6 ml subcutaneous twice daily was started. The patient responded to the treatment and discharged in satisfactory condition.
Case 4
A 30 years, female, presented with cough, fever, bloody diarrhoea, abdominal pain and vomiting. She was having difficulty in breathing and decreased oxygen saturation. Nasopharyngeal swab for SARS-Cov-2 rRT-PCR was positive and ground glass opacities were present in CT of chest. Features of acute mesenteric ischemia were present on CT of abdomen (Figure 4). Patient succumbed to pulmonary and abdominal complications on the same day.
Figure 1: Per-operative photograph showing extensive gangrene of the bowel loops
Figure 2: CECT abdomen coronal section showing mesenteric fat stranding along bowel (small white arrow) and wall thickening with pneumatosis intestinalis present in sigmoid colon (large white arrows)
Figure 3a: CECT abdomen sagittal section showing Aorta and its branches. Inferior mesenteric artery is not visualised (likely thrombosed) and terminal branches of superior mesenteric artery is having filling defects due to thrombus (white arrow) (Figure 3b): CECT abdomen coronal section. Liver is having air densities within portal venous branches with thickening of the wall of ascending colon with mesenteric fat stranding around bowel loops (white arrows)
Figure 4: CECT abdomen coronal section showing extensive mural thickening of small and large bowel loops with diffuse mesenteric fat stranding (white arrows)
Case 5
53 years, female, presented with cough, fever, nausea, vomiting and abdominal pain. Patient was not maintaining oxygen saturation and was SARS-Cov-2 RT-PCR positive. CT of chest was suggestive of ground glass opacities and features of acute mesenteric ischemia were present on CT of abdomen. Anticoagulant was started and the patient was managed conservatively but succumbed to pulmonary and abdominal complications of covid-19.
There should be high index of suspicion of acute mesenteric ischemia if a Covid-19 patient develops gastrointestinal symptoms during the course of the disease so that prompt diagnosis can be made before the gangrene sets in. If appropriately managed on time several patients can be saved.
Arterial and venous thrombosis leading to acute mesenteric ischemia can have multiple presentations depending on the extent of involvement. Some patients present with bloody diarrhoea, abdominal pain, nausea and vomiting and some develop features of peritonitis. Some responds to conservative measures if gangrene is not present and some patients requires exploratory laparotomy if bowel necrosis and gangrene is present [6].
Conflict of interest: no relevant conflict of interest
Consent: Informed consent was obtained from all individual participants included in the study
Ethical approval: no ethical approval required
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