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Research Article | Volume 2 Issue 2 (July-Dec, 2021)
Surgical Intervention in Appendectomy for Pregnant Women and Risk Factors for Pregnancy Loss
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1
M.B.Ch.B.-C.A.B.O.G. Iraqi Ministry of Health and Environment,Thi Qar Health Office, Habbobi Teaching Hospital for Obstetrics & Gynecology, Thi-Qar, Iraq, 64001
2
M.B.Ch.B.-F. I.C.M.S.-D.G.O. Iraqi Ministry of Health and Environment, Thi Qar Health Office, Bint Al-Huda Maternity & Children Hospital, Thi-Qar, Iraq, 64001
3
M.B.Ch.B.-D.G.O. Iraqi Ministry of Health and Environment, Thi Qar Health Office, Al-Rifai Hospital, Thi-Qar, Iraq, 64001
Under a Creative Commons license
Open Access
Received
May 10, 2021
Revised
May 25, 2021
Accepted
Sept. 20, 2021
Published
Sept. 30, 2021
Abstract

The study was conducted in Al-Hussein Teaching Hospital, Thi-Qar, Iraq. With the development of surgery, it became apparent that laparoscopic operations, including appendectomy, are a good alternative open operation, including in pregnant women. This paper aims to improve the way video laparoscopy in pregnant women with acute appendicitis. Data were collected for pregnant women who underwent appendicitis surgery from Al-Hussein Teaching Hospital, Thi-Qar, Iraq. 10 women who underwent appendectomy and surgical intervention were separated. Treatment of acute appendicitis during pregnancy is also a challenge for surgeons. There is a large number of papers indicating the risks and benefits of both open and laparoscopic appendectomy. The main risk is associated with abortion after laparoscopy. The article discusses the safety issues of diagnostic procedures and laparoscopic interventions during pregnancy, surgical tactics in acute appendicitis, and independent risk factors for abortion.

Keywords
Important Note:

Key findings:


Key findings of the abstract include the recognition of laparoscopic appendectomy as a favorable option for pregnant women with acute appendicitis. It highlights the challenge of managing appendicitis during pregnancy, discussing the risks and benefits of open versus laparoscopic surgery and addressing safety concerns and independent risk factors for abortion associated with laparoscopy.


What is known and what is new?
The study from Al-Hussein Teaching Hospital, Iraq, explores laparoscopic appendectomy's suitability in pregnant women with acute appendicitis, acknowledging its benefits over open surgery. It addresses safety concerns, surgical tactics, and independent risk factors for abortion, aiming to enhance the management of appendicitis in pregnant patients through improved surgical techniques and safety measures.


What is the implication, and what should change now?
The study from Al-Hussein Teaching Hospital, Iraq, addresses laparoscopic appendectomy as a viable alternative to open surgery in pregnant women with acute appendicitis. It highlights the risks, particularly abortion, associated with laparoscopy during pregnancy, emphasizing the need for improved surgical techniques and safety measures to optimize patient care and outcomes.
 

INTRODUCTION:

The surgery method (open or laparoscopic appendectomy) does not significantly affect the development of pregnancy  complications such as loss or premature birth. However, open appendectomy is associated with a significantly increased  risk of infectious wound complications, a longer period of analgesia, hospitalization, and causes worse cosmetic  outcomes. There is one description of successful laparoscopic appendectomy in the third trimester of pregnancy [1]. However, it is not widely spread and requires further research. It is necessary to remember the risks of damage to the pregnant uterus during laparoscopy at any stage of pregnancy. The surgical technique in pregnant women with all forms of acute appendicitis is not different from that in the general population. Still, it modifies access according to gestational age, requires the gentlest techniques, and avoids uterine contact. After entering the abdominal cavity, the table with the pregnant woman should be placed in the left lateral position. For the installation of the first trocar, an open technique is recommended. Carboxyl teal peritoneum should be kept as low as possible, no more than 10-12 mm Hg.  Before the operation, the level of the fundus of the uterus should be determined; if this is not done by palpation, an ultrasound examination should be performed. In the early stages of pregnancy (up to the thirteenth week), placing the first trocar above the navel in the midline is recommended. All other instruments are inserted under strict visual control from the peritoneal side.


In many cases, acute appendicitis (OA) development during pregnancy leads to a non-standard emergency for  obstetricians and gynecologists and is a complex emergency medical problem. This condition, which arises unexpectedly, can develop at any gestational age [2-4]. At the same time, the most difficult issues are the diagnosis and the choice of optimal treatment methods for  prolonged pregnancy, which are associated with the limited possibilities of using modern video-endoscopic research  methods. Several authors relate the atypicals of the clinical picture and the difficulty in diagnosing acute appendicitis in  late pregnancy with a change in the topography of the cecum and appendix [5-13].  


Ascending and lateral displacement of the cecum  and appendix, possible curvatures, appendix dilation  and periapical adhesions in pregnant women with  prolonged pregnancies can contribute to pathological  changes in the appendix and lead to the development of  acute appendicitis [5]. Of course, hypothetically, appendicitis may occur in a certain part  of pregnant women who have periods. Prolonged pregnancy and can lead to disturbances in the motor evacuation from the side of the appendix.


However, how can we explain cases of acute appendicitis in the early stages of pregnancy (first trimester), when the topography of the segment is not disturbed, or there is a posterior retroperitoneal position of the process, that is when the displacement of the organ is unlikely. 


Difficulties in diagnosis are associated with the enlarged uterus displacing the internal organs from their familiar places, especially for such a mobile part of the intestine as the appendix. The appendix can travel up to the liver and down to the pelvic organs. In addition, nausea, vomiting, and some other symptoms of appendicitis can occur in normal pregnancies.  Diagnosis of appendicitis causes difficulties outside pregnancy; therefore, a highly qualified surgeon and additional methods in ultrasound and laparoscopy are required for its diagnosis in a pregnant woman. Often there are cases when a patient with appendicitis is treated on an outpatient basis for other diseases, forgetting about the possibility of an acute surgical case. 
The displacement of the cecum facilitates the development of appendicitis during pregnancy with the appendix due to the growth of the uterus, which leads to its bending and expansion, deterioration of its blood  supply, and impaired emptying. A tendency facilitates this to constipation, which leads to stagnation of intestinal contents and an increase in the virulence of  the intestinal microflora. 


The most common signs in pregnant women with acute appendicitis are - acute abdominal pain, which acquires a persistent aching character and moves to the site of localization of the appendix (right lateral  abdomen, right hypochondrium), nausea, vomiting,  fever, and general changes: blood test - erythrocyte  white.

 

An increase in abdominal pain is observed when turning from the left side to the right side. 
Manifestations of the disease in the first trimester do not differ from those of non-pregnant women, but the  diagnosis can be difficult. Symptoms of acute appendicitis - nausea, vomiting, lower abdominal pain  can be signs of early toxicities and risk of miscarriage.  Increased body temperature, a white-coated tongue, and localized pain on palpation in the right iliac region are  most likely indicated appendicitis. 


The clinical picture of acute appendicitis in the second and third trimesters is less clear due to the atypical location of the appendix. After 20 weeks of pregnancy, the cecum with the appendix is displaced up and back by the growing uterus, and at the end of pregnancy, the appendix may be closer to the right kidney and gallbladder. From the second half of pregnancy, the pain is less pronounced; there is no tension of the rectus abdominal muscles in response to palpation, symptoms of irritation of the peritoneum are mild, which are associated with stretching of the anterior abdominal wall in a pregnant woman; There may be no pronounced leukocytosis. Establishing the correct diagnosis is facilitated by identifying the positive symptoms of Obraztsova in a pregnant woman (painful tension of the muscles of the right iliac region when lowering the raised right leg). 
 

MATERIAL AND METHOD:

This study focuses on surgical intervention in appendices for pregnant women and risk factors for pregnancy loss. Data were collected for pregnant women who underwent appendicitis surgery from Al Hussein Teaching Hospital, Thi-Qar, Iraq.

 

10 women who underwent appendectomy and surgical intervention were separated. 


Statistical software was used STAT v.25 for descriptive analysis through measures of central tendency and Dispersion of continuous variables and discrete variables' absolute and relative frequencies. In addition, a comparison of proportions of the variables of interest was evaluated Through the Chi-Square test. 


The following shows the complications of childbirth and still birth. It is offered more frequently in traditional appendectomy, and Laparoscopy may be a safe alternative to traditional surgery for appendicitis Severe in pregnant women, thus avoiding the risk of perinatal death.
 

RESULT:

 

 

Figure 1- Patient Outcomes in Appendicitis Surgery for Pregnant Women 

 

 

Figure 2- Obstetric and Surgical Complications

 

 

 

Figure 3 – Explain the P-Value of the Result. 

 

Acute appendicitis during pregnancy is the most common surgical disease in pregnant women and the main reason for surgical treatment. 

 

Acute appendicitis by itself, surgical trauma, and complications that may develop in this case are not indifferent either to a pregnant woman or to her future child. Complications of acute appendicitis in the first place include perforation of the appendix and peritonitis. The incidence of these complications is increased during pregnancy.  

 

This is explained, among other things, by the delay in surgical treatment at the diagnostic stage, which is due to the peculiarities of the clinical picture.  Manifestations of acute appendicitis, as a rule, are more erased in this category of patients. In addition, there are features in laboratory and instrumental findings.  Pregnancy significantly narrows the range of diagnostic tools used to diagnose acute appendicitis. 

 

The high rate of passive appendectomy, which ranges from 25% to 50% in pregnant women compared to 16% in non-pregnant women, explains the operation's impact. (Figure 1, 2, 3).

CONCLUSION:

The proposed method for performing laparoscopy improves the diagnosis and surgical treatment of acute appendicitis in pregnant women. It enhances the quality of medical and social rehabilitation of patients. Video  laparoscopy is the most important diagnostic method  for acute appendicitis in pregnant women; it can also be diagnosed from treatment. However, since laparoscopy  is an invasive diagnostic method, it should be used in  complicated diagnostic cases where the clinical picture  remains unclear. 


Funding: No funding sources


Conflict of interest: None declared.


Ethical approval: The study was approved by the Institutional Ethics Committee of Habbobi Teaching Hospital for Obstetrics  & Gynecology.
 

REFERENCES:
  1. Pastore, Patricia A., Dianne M. Loomis, and John Sauret. "Appendicitis in pregnancy." The Journal of the American Board of Family Medicine 19.6 (2006): 621-626. https://www.jabfm.org/content/19/6/621.short 
  2. Tracey, Michelle, and H. Stephen Fletcher. "Appendicitis in pregnancy." The American Surgeon 66.6 (2000): 555-560. https://doi.org/10.1177/000313480006600606 
  3. Rychagov, G.P., et al. "Modern Issues of Diagnosis and Treatment of Acute Appendicitis in Pregnant Women." Surgery News, vol. 19, no. 5, (2011).
  4. Rychagov, G. P., et al. "Modern Aspects of Diagnostics and Treatment of Acute Appendicitis During Pregnancy." Novosti Chirurgie, vol. 19, no. 5, (2011), pp. 23-31.
  5. Miloudi, N., et al. "Acute appendicitis in pregnancy: specific features of diagnosis and treatment." Journal of visceral surgery 149.4 (2012): e275-e279. https://doi.org/10.1016/j.jviscsurg.2012.06.003 
  6. Jung, Soo Jung, et al. "Appendicitis during pregnancy: the clinical experience of a secondary hospital." Journal of the Korean Society of Coloproctology 28.3 (2012): 152. https://doi.org/10.3393/jksc.2012.28.3
  7. Stepp, Kevin, and Tommaso Falcone. "Laparoscopy in the second trimester of pregnancy." Obstetrics and Gynecology Clinics 31.3 (2004): 485-496.  https://doi.org/10.1016/j.ogc.2004.05.002 
  8. S. Al-Qudah, M. Amr, A. Sroujieh, A. Issa, M. "Appendectomy in pregnancy: the experience of a university hospital." Journal of Obstetrics and Gynaecology 19.4 (1999): 362-364. .  https://doi.org/10.1080/01443619964643 
  9. Abbasi, N., V. Patenaude, and H. A. Abenhaim. "Management and outcomes of acute appendicitis in pregnancy—population‐based study of over 7000 cases." BJOG: An International Journal of Obstetrics & Gynaecology 121.12 (2014): 1509-1514. https://doi.org/10.1111/1471- 0528.12736 
  10. Cheng, Han-Tsung, et al. "Laparoscopic appendectomy versus open appendectomy in pregnancy: a population-based analysis of maternal outcome." Surgical endoscopy 29 (2015): 1394-1399. .  https://doi.org/10.1007/s00464-014-3810-5 
  11. Guttman, Rachelle, Ran D. Goldman, and Gideon Koren. "Appendicitis during pregnancy." Canadian family physician 50.3 (2004): 355-357. https://www.cfp.ca/content/50/3/355.short 
  12. Ueberrueck, Torsten, et al. "Ninety-four appendectomies for suspected acute appendicitis during pregnancy." World journal of surgery 28 (2004): 508-511. https://doi.org/10.1007/s00268-004-7157- 2 
  13. Yilmaz, Hatice Gulsen, et al. "Acute appendicitis in pregnancy—risk factors associated with principal outcomes: a case control study." International Journal of Surgery 5.3 (2007): 192-197. https://doi.org/10.1016/j.ijsu.2006.05.005 
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