Eczema is a skin problem that causes skin irritation, itchiness, roughness, and inflammation. There are different stages of eczema that are noticed in people from several age groups across the globe. Eczema is a common condition that’s estimated to affect up to 20% of children and adults worldwide. The most common type of eczema is Atopic Dermatitis (AD). It causes skin inflammation and irritation. Vitamin C is one of the most powerful antioxidants that protect skin barriers and help prevent skin-damaging diseases. Consuming vitamin C can help treat eczema and vitamin deficiency. Vitamin C also helps prevent water loss from the skin and therefore, maintains the skin hydration and the pH balance of the skin. A concentration of 65 gm-100 gm is extremely beneficial for the epidermal skin layers. In this review, we will summarize the effects of vitamin C on atopic dermatitis, and highlight the potential of vitamin C as a therapeutic strategy to treat AD, emphasizing the clinical application of vitamin C as an adjuvant for drugs or physical therapy in AD.