Context:The incidence of breast cancer is steadily rising in India. The management and prognosis of breast cancer requires evaluation of Estrogen Receptor (ER), Progesterone Receptor (PR) and HER-2/neu as they have a great influence on the clinical outcome. Receptor status has thus become most informative in the molecular classification of breast tumours and their clinical assessment for treatment and further outcome. Aims: To assess the age incidence, gender predilection along with incidence of ER, PR, HER-2/neu in breast cancer at our institution. Settings and Design:Study population comprised of all patients with carcinoma breast (women and men) which have been proved on histopathology. Study design: Prospective study.Methods and Material:151 cases of breast carcinoma received in the department of pathology of Indira Gandhi Medical College, Shimla over a period of 24 months (May 2014 to May 2016) were analyzed with reference to ER, PR and HER-2/neu reactivity pattern. The histological type and grade of the tumour were analyzed and correlated with receptor status.Statistical Analysis Used: descriptive statistical analysis and presented in terms of percentage. Results: Age of the patient varied from 23-92 years, the mean age being 49 years. 97.4% cases were female patient while, males constituting 2.6% cases. The mean age in male patients was 64.5 years. Majority of the tumours were infiltrating ductal carcinoma- not otherwise specified (NOS) and histologically grade II predominantly. Majority of the cases belonged to luminal A category, followed by triple negative tumours. Conclusions: Prognostic accuracy improves with incorporation of IHC into the histopathology report along with the traditional TNM staging and histological grading. The determination of receptor status is also helpful in planning the appropriate treatment of the patient.

Hepatoid adenocarcinoma of stomach is a rare and clinically aggressive tumor. Most of these cases are associated with increased production of alpha fetoprotein, but not all AFP producing tumors have hepatoid features histologically. We report a case of 64 years male, with elevated Alpha Fetoprotein levels. The patient underwent gastrectomy. HPE suggested a diagnosis of hepatoid adenocarcinoma. PAS staining also revealed PAS positive hyaline globules.