This study investigated how loan management impact on performance of Deposit Money Banks in Nigeria covering the period 2000 - 2019 with special emphasis on First Bank, Access Bank, and United Bank for Africa. The model in the study used secondary data obtained from annual report and accounts of the selected banks for the period under study to determine the effect of loan management (through Loans and Advances and Non-performing loans of banks) on performance of the selected banks (through Return on Asset). The Data were analyzed using ratio analysis and Ordinary least square method. The specific finding of the work is that return on asset has inverse relationship with non-performing loans while they are positively related to loans and advances. The conclusion is that there is a significant relationship between bank performance and loan management. The study then suggests that deposit money banks should set up an efficient structure for loan management.