Ganga River is one of the prime individualities of Hinduism, Ganges is not only a source of water but it is deliberated a Goddess Mother who always gives everything to her children the Ganga is accredited in Rigveda,500BC Hippocrates, wrote about the therapeutic of disease with water. Ernest Hankin, a British bacteriologist, reported in 1896 on the presence of antibacterial activity against Vibrio cholera. It has been proven that Bacteriophage is found in greater quantity inside the Ganges than other rivers. This review is mainly focused on the role of Ganga Phages in different severe diseases and provides an overview of the potential of phage therapy as a resource of treating or preventing human diseases, this review shall help the policymakers to choose the best methods & criteria for phage therapy in the treatment of many severe diseases.