Knowledge as an intangible asset is needed in companies such as the oil and gas to enhance the workers’ degree of responsiveness to market conditions. This relationship seems not play out in the foreign oil and gas companies operating in Nigeria. The knowledge hiding behaviour, distrust, rarity of innovative Nigerian workers and foreign workers’ dominance that characterise the industry seems to be undermining the knowledge transfer and employment essence of the Nigerian Local Content Act. Consequently, this study investigates the moderating effects of trust and collaboration on knowledge responsiveness and innovative work behaviour of Nigerian workers in the foreign oil and gas companies. The study adopts cross sectional survey design, proportionate stratified random sampling and simple random sampling techniques to collect data from the indigenous workers. The result of the regression analysis shows that trust and collaboration moderates the relationship between knowledge responsiveness and innovative work behaviour. Thus, the strength of the relationship between knowledge responsiveness and innovative work behaviour of Nigerian workers in these companies can be increased or decreased through trust building and participation in knowledge application. The scant literature and the cross-sectional nature of the data are the main limitations. However, the result of the study will help the managers understand the importance of trust building and involvement of indigenous workers in the achievement of innovative work behaviour.