Neurofibromatosis is an autosomal dominant disease with a wide variety of clinical manifestations. Neurofibromas are the characteristic lesions present in the patients. This disorder is associated with important anaesthetic considerations, mainly when neurofibromas occur in cervical region, leading to restricted neck movement, difficult laryngoscopy and tracheal intubation. We report the anaesthetic management of 37 year old patient K/C/O Neurofibromatosis with large neurofibromas in cervical region posted for open cholecystectomy under general anesthesia. We performed a brief review of literature with the aim of optimizing the anaesthetic management and reducing the number of complications associated with the systemic manifestations of this syndrome.