ackground: Telemedicine is the use of advanced telecommunications technologies for the purposes of making diagnoses, conducting research, transferring patient data, and/or improving disease management and treatment in remote areas. In the right circumstances, Telemedicine offers a cost-effective alternative to the traditional methods of health care delivery. Objectives: The main objectives of the study was to assess the level of knowledge regarding Telemedicine, to develop and administer a Structured Teaching Programme on knowledge regarding Telemedicine, to assess the effectiveness of Structured Teaching Programme and to determine the association of post test knowledge with selected socio-demographic variables regarding Telemedicine. Methods and material: A pre-experimental (one group pre-test post-test) design was used for the study. Total 60 students of B.Sc. Nursing 3rd year and 4th year of Sister Nivedita Government Nursing College, IGMC, Shimla (H.P.) were selected by using convenience sampling technique. A self structured knowledge questionnaire was used to assess the knowledge regarding Telemedicine. After conducting pre-test, structured teaching program was provided. The knowledge score of pre-test and post-test was compared. The gathered data was analyzed by using descriptive and inferential statistics. Results: The study finding shows that the mean post-test knowledge score (21.70%) was higher than the mean pre-test knowledge score (15.10%). which was statistically significant. Conclusion: It was concluded that the structured teaching program was effective in increasing the knowledge of students of B.Sc. Nursing 3rd year and 4th year regarding Telemedicine.